The drug "Prestans" is often used in the practice of cardiologists. It dilates peripheral arterioles and coronary arteries, reduces vascular stress, and improves coronary blood flow. Since the preparation contains quite serious substances, not all people can use it. In addition, it causes a large number of adverse reactions.
The Russian drug "Prestans" is presented on the pharmaceutical market in the form of tablets. Each tablet contains perindopril arginine and amlodipine besylate.
Perindopril from the gastric tract enters the bloodstream. 65-95% of substances are absorbed. Food reduces absorption by 35%. The highest level of perindopril in the blood is observed one hour later. The substance in the liver is split into metabolites, a fifth of which is occupied by perindoprilat. The half-life process starts after a day. The metabolites are excreted by the kidneys. Perindopril does not cumulate.
Amlodipine enters the bloodstream in the same way as perindopril. Absolute bioavailability is 64-80%. It is absorbed a little slower. The maximum level reaches after 6-12 hours. Food does not affect the absorption process. The substance is broken down very slowly in the liver. The metabolites formed during decomposition have no therapeutic effect. They begin to be excreted after 45 hours. The kidneys and, to a lesser extent, the intestines are involved in the process.
"Prestans" has shown itself to be excellent in the treatment of arterial hypertension and coronary heart disease. It is used for stable angina pectoris.
Since the drug can provoke allergies, it is not prescribed for those patients who have ever had Quincke's edema. Do not use "Prestans" for low blood pressure, renal failure, cardiogenic shock and problems with the left ventricle.
Minority and allergy to the components of the drug also act as contraindications. The composition of the drug includes lactose, based on this, it can be concluded that it should not be used in cores with lactose intolerance or deficiency.
Mode of application
Medication "Prestans" is taken daily, 1 tablet in the morning on an empty stomach. Blood pressure should be monitored while taking this inhibitor. The dose can be changed up or down, but only with the consent of the doctor.
"Prestans" copes well with the tasks, but other organs may suffer during the treatment. Often, when taking medication, cores notice drowsiness, vertigo, slight dizziness, frequent headache, blurred vision, muscle spasms, decreased blood pressure, increased pulse, shortness of breath, upset gastrointestinal tract, edema, tinnitus, fatigue, asthenia, skin itching, rash.
Less common are allergic reactions, sleep disturbances, mood swings, depressive conditions, tremors, fainting, bronchospasm, rhinitis, swelling of the face and mucous membranes, hair loss, sweating, muscle pain, impaired urination, kidney failure, weight gain or loss.
It is extremely rare for doctors to observe in their patients changes in blood and urine parameters, confusion, hypertension, angina pectoris, arrhythmia, stroke, vasculitis, pneumonia, hepatitis, Quincke's edema, dermatitis, renal failure, problems with potency.
Price and analogues
The cost of the drug "Prestans" in pharmacies depends on the dosage and the number of tablets in the package. For example, 30 tablets with a dosage of 10 mg + 10 mg will cost the buyer 750 rubles, and the same number of tablets, but with 5 mg + 5 mg active ingredients, will cost 580 rubles. You can buy analogues of the drug at a lower price, "Concor", "Indapamide", "Lorista", "Noliprel".