Papaverine is an antispasmodic agent that relaxes the muscles of the internal organs. During pregnancy, Papaverine is prescribed to relieve uterine spasms. The drug relaxes the smooth muscles of the uterus and improves its blood supply, and when taken in higher doses, it additionally has a mild sedative effect. Most often, papaverine is prescribed in the first trimester of pregnancy with hypertonicity of the uterus to prevent the threat of miscarriage.
Papaverine has three forms of release: tablets, suppositories for rectal use and injection. Papaverine in the form of tablets during pregnancy is not prescribed, since it is believed that this form of release of the drug has a more pronounced side effect. It is worth noting that there have been no clinical studies of the safety of this drug during pregnancy. However, it has been used to reduce the tone of the uterus in the early stages of pregnancy for a long time, and this allows medical specialists to conclude that this drug is safe for the health of the unborn child. In any case, the use of Papaverine is prescribed only if the benefits of treatment and the expected positive effect on the course of pregnancy are higher than the possible risks to the fetus.
As a rule, during pregnancy, papaverine rectal suppositories are used. The dosage recommended by the instruction is one candle two or three times a day. Injections should be made at regular intervals, for example, every four hours. The doctor determines the duration of the course of treatment individually, but in most cases the drug is used for the shortest possible time, sufficient to achieve the desired therapeutic effect. As soon as the signs of increased uterine tone disappear, Papaverine is canceled.
In some cases, a pregnant woman may be given intravenous or intramuscular papaverine. Usually, papaverine in the form of injections is used only in emergency cases when a quick therapeutic effect is required: with intravenous, intramuscular or subcutaneous administration of the drug, spasms and the pain syndrome caused by them are eliminated much faster than with oral or rectal administration. The dose of solution for injection for a single administration may be from 10 to 20 mg. The interval between injections should be at least four hours. Intravenous papaverine injections should be performed by a qualified healthcare professional and only in a hospital setting. Subcutaneous or intramuscular injections of Papaverine are allowed at home, if the use of the drug in the form of injections is recommended by a doctor.
Please note: side effects when using Papaverine during pregnancy can be a decrease in blood pressure, dizziness, drowsiness, nausea, constipation and increased sweating. Usually, when such side effects appear, treatment is not stopped. But if taking the drug is accompanied by more pronounced symptoms, such as severe weakness or dizziness, be sure to inform your doctor about this. However, Papaverine during pregnancy is most often very well tolerated, helping to eliminate pain and spasms without any negative effect.