Acetylsalicylic acid, better known as aspirin, is one of the most popular medicines in the world. For many decades of using aspirin in medical practice, the mechanism of action it exerts on the body has been well studied, and its clinical efficacy has been repeatedly proven. Today, acetylsalicylic acid is included in the WHO list of essential medicines and in the list of vital and essential medicines in Russia.
Acetylsalicylic acid was invented by the Alsatian chemist Charles Frédéric Gerard in 1853. However, the first samples of it, suitable for the treatment of people, were obtained only in 1897. These samples were synthesized by the German chemist Felix Hoffmann in the laboratory of the pharmaceutical company Bayer, which registered the new drug under the trademark Aspirin. The first batch of aspirin in powder form went on sale in 1899, and in 1904 acetylsalicylic acid began to be produced in the form of tablets.
Currently, acetylsalicylic acid is produced under various brands: Upsarin Upsa, Aspirin Cardio, Nextrim Fast, Cardiopyrin, ASK-Cardio, Taspir, Ascopirin, Terapin, Aspitrin "," Fluspirin "," Aspikor "and others. Acetylsalicylic is also part of many popular combined painkillers, including" Citramon-P "," Askofen-P "," Excedrin "," Kofitsil-Plus "," Citrapak ", "Citramarine", etc.
Pharmacological properties of acetylsalicylic acid
Initially, aspirin was used only as an antipyretic agent. After some time, it turned out that acetylsalicylic acid also has analgesic and anti-inflammatory effects. Another important property of aspirin is its ability to thin the blood, which is used when there is a risk of blood clots.
Indications for taking acetylsalicylic acid are mild and moderate pain syndrome of various origins (headache, toothache, neuralgia, muscle pain, sore throat, painful menstruation, etc.); fever caused by infectious and inflammatory diseases; prevention of thrombosis, embolism, myocardial infarction and ischemic stroke.
Acetylsalicylic acid dosage
Aspirin is indicated for the treatment of adults and children over 15 years of age. A single dose of acetylsalicylic acid is 500 mg, the maximum single dose is 1 g. No more than 3 g of aspirin can be drunk per day. The interval between taking the pills should be at least 4 hours.
Side effects of acetylsalicylic acid
The most common side effects of aspirin are due to the irritating effect it has on the stomach. Therefore, taking acetylsalicylic acid can cause nausea, vomiting, diarrhea, and stomach bleeding. With prolonged use of aspirin, damage to the nervous system is possible, manifested by impaired coordination of movements, convulsions and clouding of consciousness. In severe cases, acetylsalicylic acid can cause toxic damage to the liver and kidneys. In addition, severe allergic reactions up to anaphylactic shock are possible.