Differelin: Instructions For Use, Price, Analogues

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Differelin: Instructions For Use, Price, Analogues
Differelin: Instructions For Use, Price, Analogues

Video: Differelin: Instructions For Use, Price, Analogues

Video: Диферелин. Укол в живот 2022, December

The medicine "Dipherelin" is prescribed by doctors to patients with various diseases of the reproductive system. This drug belongs to the group of antihormones, since it suppresses the production of luteinizing and follicle-stimulating hormones in the human body.


From the point of view of biochemistry, this drug is an artificial analogue of the natural hormone GnRH, synthesized in the body by the hypothalamus.

The composition of the drug and its cost

This medicine is produced in the form of solutions intended for subcutaneous or intramuscular administration. Its main active ingredient is triptorelin pamoate. Mannitol is also a part of "Dipherelin" used for subcutaneous injections.

The form of the drug intended for intramuscular administration contains the following additional substances:

  • mannitol;
  • polysorbate-80;
  • polymer of glycolic and lactic acid;
  • carmellose sodium.

"Diphereline" for subcutaneous administration contains 0.1 mg of active substance, for intramuscular administration - 11.25 mg or 3.75 mg.

This medicine is quite expensive in pharmacies. The price for it is about 2000-2500 rubles. for 2018 (lyoph. vial 0.1mg No. 7).

When can be appointed

Doctors can prescribe this drug to patients if they have, for example, problems such as:

  • uterine fibroids;
  • prostate cancer;
  • endometriosis;
  • premature puberty in adolescents.

Also, this medicine is used for female infertility to stimulate the ovaries in combination with gonadotropins.

What are the contraindications

Not all patients can take this drug, like almost any other. Contraindications to treatment with Dipherelin are, for example, diseases such as:

  • hormone-independent prostate cancer in men;
  • polycystic ovary syndrome in women;
  • osteoporosis;
  • allergy to any components of the drug.

In addition, pregnant and lactating women should not drink Dipherelin. Also, this drug is contraindicated in men after testicular surgery.

Instructions for use

"Dipherelin", intended for subcutaneous administration, is most often used in IVF protocols. Moreover, in most cases, doctors prescribe 1 ampoule of this medication per day, starting from the second day of menstruation.

"Diphereline" 11.25 mg is usually administered to patients no more than 1 time in three months. Men can inject this solution any day. Women are allowed to take injections only in the first 5 days of the menstrual cycle.

"Diphereline" 3.75 mg is used for the treatment of diseases of the reproductive system most often. Patients are usually injected with this drug once a month.

Side effects

During treatment with Dipherelin, patients may experience the following side effects:

  • urticaria, Quincke's edema;
  • decreased potency and vaginal dryness;
  • headache;
  • obstruction of the ureters;
  • nausea, vomiting, asthenia;
  • change in the size of your breasts or testicles;
  • demineralization of bones;
  • visual impairment;
  • hot flashes.

Drug substitutes

Thus, there are quite a lot of side effects of "Dipherelin". If necessary, this medicine can be replaced with, for example, drugs such as:

  • spray "Buserelin";
  • capsules "Zoladex".

In addition, the analogues of Diferelin are Lukrin Depot, Decapeptil and Eligardt.

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