Clofranil: Instructions For Use, Analogs, Side Effects

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Clofranil: Instructions For Use, Analogs, Side Effects
Clofranil: Instructions For Use, Analogs, Side Effects

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Clofranil is an antidepressant drug manufactured by an Indian pharmaceutical company. It is used to treat both adults and children. It is released only by prescription. The dosage regimen is determined by the doctor, while patients should carefully study the instructions before starting therapy.

"Clofranil": instructions for use, analogs, side effects
"Clofranil": instructions for use, analogs, side effects

Composition and form


The drug "Clofranil" is presented on the pharmaceutical market in the form of blue rounded tablets. The composition of the product is dominated by lomipramine hydrochloride. "Klofranil" is sold in aluminum blisters.


Clofranil is a balanced tricyclic antidepressant. It has a thymoanaleptic effect; inhibits the reuptake of serotonin and norepinephrine; reduces the activity of serotonin receptors; stabilizes serotonergic and adrenergic transmission; balances systems that are unstable in depressive states.

The drug has analgesic, anti-bulimic properties, copes well with enuresis. The antidepressant effect is noticeable after a week of use.


Clofranil tablets are quickly and fully absorbed from the digestive tract. The bioavailability of substances is 50%. After taking the drug, the maximum level of substances in the blood is observed after 4 hours. The connection with blood proteins is established by 98%.

The half-life of lomipramine hydrochloride lasts for 21-36 hours. More than half of the dose is excreted by the kidneys, the other part by the intestines. Excretion of clomipramine unchanged is only 1%, 99% leaves the body in the form of hydroxylated metabolites.



For adults, the drug "Clofranil" is used during the treatment of depressive conditions of various origins. With the help of it, the psychoemotional state of patients suffering from schizophrenia and psychopathy is supported.

Lomipramine hydrochloride proved to be excellent in depressive disorders of a neurotic and reactive nature, obsessive-compulsive syndrome, cataplexy.

Doctors note excellent dynamics in the treatment of this drug in their patients suffering from phobias and panic attacks.

Pediatricians prescribe "Clofranil" to children who have obsessive-compulsive syndrome. It is used to diagnose nocturnal enuresis in adolescents.


Doctors do not recommend taking Clofranil tablets if an allergy to the ingredients of the drug has been previously identified. It is worth giving it up even if you are intolerant of drugs from the dibenzazepine group.

In no case should you take lomipramine hydrochloride with monoamine oxidase inhibitors, moclobemide. At least 2 weeks should elapse between taking these drugs.

It is dangerous to treat with antidepressants after a recent heart attack, as well as in congenital QT-interval prolongation syndrome.

During pregnancy and during breastfeeding, drug treatment is dangerous for the baby, since the active ingredient is able to penetrate the placental barrier and into breast milk.

Pediatricians use Clofranil only for children over 5 years old.

Antidepressants should be administered very carefully if there is a history of seizures, organic brain disease, and tumors of the medulla. Patients suffering from chronic alcoholism, cardiovascular diseases and taking antipsychotics and thyroid hormones should also be monitored.

In old age, during therapy, the doctor should carefully monitor vital indicators, since the drug is able to make significant changes in the work of some organs.

Ophthalmologists react with caution to such therapy in relation to people with intraocular hypertension, glaucoma.

Mode of application


Clofranil tablets are recommended to be taken during meals or immediately after meals. The dosage regimen is determined by the attending physician. There are average doses. For example, with depression, phobias, treatment begins with 75 mg of the drug per day (the dose is divided into 3 doses). After a few days, the amount of the drug is gradually increased to 150 mg, and in severe cases, up to 300 mg. After stabilization of the patient's condition, the patient is transferred to a maintenance dose of 100 mg per day.

Since older people react more sharply to the drug, they are prescribed a lower dosage of 10-12.5 mg per day. The dose is gradually increased to 30-50 mg.

With cataplexy, 25-75 mg of lomipramine hydrochloride is prescribed per day. Panic attacks are treated with a drug in a daily dosage of 10-12, 5 mg. If the tablets do not help, the dose is increased.

It is impossible to abruptly stop treatment. Doctors recommend taking courses for six months. During this time, the dose of the drug should be very gradually reduced.

Children with obsessive-compulsive syndrome are recommended to start therapy with 12.5 mg of the drug. The number of tablets is increased within 14 days. The maximum possible dose for children is 200 mg.

In the treatment of nocturnal enuresis in children 5-8 years old, 20-30 mg of the drug is prescribed per day, 9-12 years old - 20-50 mg, from 12 years and older - 25-75 mg. The daily dose can be consumed with dinner once a day. The duration of treatment for enuresis is 1-3 months. The dosage is reduced gradually.

Side effects

On this side, the patient will face a headache, drowsiness, dizziness, anxiety, temporary speech and sleep disturbances, hallucinations, decreased concentration, hypertonicity, tremors, convulsions.

Tinnitus, vision and taste problems may occur.

… Since "Clofranil" is presented in pill form, it can provoke nausea, vomiting, diarrhea, problems with appetite, hepatitis and jaundice. Most often, these side effects indicate an overdose.

Lomipramine hydrochloride inhibits the work of the heart muscle and cerebral vessels. Against the background of therapy, tachycardia, hypotension, and increased pressure may appear. Violations of intracardiac patency are extremely rare.

… Sometimes endocrinologists note in people being treated with antidepressants, weight gain, problems with libido. In women, menstrual irregularities, pain during critical days, and enlargement of the mammary glands are possible.

Sometimes experts note in patients signs of leukopenia, thrombocytopenia, eosinophilia, purpura. That is why laboratory blood tests should be carried out regularly during treatment.

In addition, patients taking Clofranil tablets may experience urinary retention, allergies, hair loss, and deterioration of tooth enamel.

Analogs of the drug and reviews


"Clofranil" can be replaced by identical means. Its analogue is the Italian antidepressant drug Anafranil. The same active substance predominates in its composition. Indications, contraindications and even the dosage regimen is identical to the drug "Clofranil".

Judging by the reviews, an antidepressant is a fairly effective drug, but it causes many side effects. The most striking are drowsiness, apathy, decreased libido. He copes with his tasks in a short time - relieves depression, relieves of fears, anxiety and suicidal thoughts. The drug is inexpensive, but it is very difficult to find it in the pharmacy network.

When buying an analogue, you should pay attention that a prescription must be issued for the drug that is in the pharmacy. A pharmacist cannot sell, for example, Anafranil if the prescription is for Clofranil. Before buying the drug, you should carefully read the instructions.

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