Misoprostol: Instructions For Use, Indications, Price

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Misoprostol: Instructions For Use, Indications, Price
Misoprostol: Instructions For Use, Indications, Price

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Peptic ulcer is diagnosed in every second patient with recurrent heartburn and pain. Treatment should be comprehensive and cannot be limited to antacids. Misoprostol may be prescribed as a therapy.

Misoprostol: instructions for use, indications, price
Misoprostol: instructions for use, indications, price

"Misoprostol" is a drug with a pronounced cytoprotective effect. Misoprostol hydrate is used as an active ingredient. Of the additional components, the following substances can be included:

  • Silica gel (micronized).
  • Carboxymethyl cellulose.
  • Ricin oil.

The drug is available in the form of white round tablets. The retail package can contain from 10 to 40 tablets.

Pharmacological action of the drug, its pharmacokinetics

"Misoprostol" is a synthetic analogue of prostaglandin E1. This substance is capable of exerting a cytoprotective effect, which is expressed in additional stimulation of the glandular cells of the stomach and increased secretion of mucus by its walls. The drug reduces the production of pepsin.

Misoprostol can be used in gynecology. The drug provokes a contraction of the smooth muscles of the myometrium, thereby expanding the walls of the uterus.

The drug is absorbed mainly in the gastrointestinal tract. Its maximum concentration is reached after 12 minutes (the active ingredient is misoprostolic acid). It is excreted mainly by the kidneys and liver.

Indications for the use of the drug

Misoprostol has a limited number of indications and must be prescribed by a physician. The main indications for the use of the drug are:

In gastroenterology:

  • Stomach ulcer.
  • Prophylaxis in patients taking pain medications for a long time.
  • Diseases of the duodenum.
  • Perforated ulcers.

Gynecology:

Co-administration of the drug with mifepristone is used to terminate early pregnancy

Method of taking the drug, dosage regimen

For early termination of pregnancy:

To terminate pregnancy, use the following scheme:

  1. A single oral dose of 600 mg of mifepristone.
  2. After 3-4 days, 400 mg of misoprostol.

If after 2 days there is no bleeding, you should contact your gynecologist.

As an antiulcer agent

The daily dosage of the drug is 1200 mg per day. The dose is divided into 2–4 doses. In patients with severe renal failure, the daily dose is reduced to 400 mg. The course of treatment is from two weeks to 6 months.

Side effects of the drug "Misoprostol"

  • Dyspeptic disorders: constipation, flatulence, diarrhea.
  • Allergic reactions of immediate type.
  • Increased fatigue.
  • Pain similar to premenstrual syndrome.
  • Dysmenorrhea.
  • Change in body weight.

Contraindications to the use of the drug

  • The period of pregnancy, as it can provoke a miscarriage.
  • Renal failure
  • Children under the age of 18.
  • Sensitivity to the components of the drug.
  • Arterial hypertension.

Drug interactions

  1. The simultaneous use of "Misoprostol" with antacids reduces the concentration of the first drug in the blood plasma, and accordingly reduces its effectiveness.
  2. Joint reception with acenocoumarol reduces the antiaggregatory effect of the drug.
  3. In combination with diclofenac sodium and indomethacin, the side effects of both drugs are enhanced.

Analogues of the drug, its price

It should be noted that the drug has no structural analogs. It is possible to single out only analogues of the action of the drug. They will be structural analogs of mefipristone, which is used to terminate pregnancy. The price of Misoprostol is 2000-2500 rubles.

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